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In category NewsGSK announces positive pivotal phase III data for 5-in-1 Meningococcal ABCWY vaccine candidate
On March 14th, 2023, GSK announced positive headline results from the phase III trial (NCT04502693) evaluating the safety, tolerability, and immunogenicity of its MenABCWY combination vaccine candidate, administered as two doses given six months apart in healthy individuals aged 10-25 years. Invasive meningococcal disease (IMD), a major cause of meningitis and septicaemia, is an uncommon […]
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In category BlogConducting successful clinical trials for influenza vaccines
Finding more effective vaccines for the constantly moving target of influenza with longer-term immunity is a cause worth pursuing. For example, the mRNA technology opens opportunities to develop and manufacture effective vaccines closer to the flu season, with a better match to the circulating viruses. But what are successful clinical trials made of? Mika Rämet, […]
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In category NewsModerna announces mRNA-1345, an investigational Respiratory Syncytial Virus (RSV) vaccine, has met primary efficacy endpoints in phase 3 trial in older adults
On January 17th, Moderna announced positive topline data from its Phase 3 trial of mRNA-1345, an investigational mRNA vaccine targeting respiratory syncytial virus (RSV) in older adults. RSV, a highly contagious seasonal respiratory virus and a leading cause of lower respiratory tract infections and pneumonia, causes a particularly large burden of disease in infants and […]
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In category NewsPfizer announces positive findings in global maternal immunization trial for its RSV vaccine candidate
On November 1st, Pfizer announced positive top-line data from the Phase 3 clinical trial (NCT04424316) MATISSE (MATernal Immunization Study for Safety and Efficacy) investigating its RSV vaccine candidate, RSVpreF, when administered to pregnant participants to help protect their infants from RSV disease after birth. RSV is a contagious virus and a common cause of respiratory […]
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In category BlogVaccine development thrives – Finland offers unique possibilities
Finland has strong expertise in high-quality vaccine research based on decades of experience. In addition, exceptional national data resources increase the attractiveness of Finland for international research investments. When the overall impact of vaccines is studied on a large scale, in addition to clinical trials aimed at obtaining a license for marketing authorization, important evidence […]
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In category NewsNew medicine to protect babies and infants from respiratory syncytial virus (RSV) infection
European Medicines Agency (EMA) has recommended a marketing authorisation in the European Union for Beyfortus (nirsevimab) for the prevention of Respiratory Syncytial Virus (RSV) lower respiratory tract disease in newborn babies and infants during their first RSV season. RSV can be serious, especially in infants. It is the most common cause of lower respiratory tract infections, […]
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In category NewsEvaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age
A randomized, placebo-controlled phase 2–3 trial examined the safety, immunogenicity, and efficacy of two doses of the BNT162b2 vaccine administered 21 days apart in 5-to-11-year-old children. 2,268 children were randomly assigned to receive two injections, 21 days apart, of either the BNT162b2 vaccine (at a dose level of 10 μg, selected during phase 1) or […]
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In category NewsEffectiveness of the quadrivalent high-dose influenza vaccine for prevention of cardiovascular and respiratory events in people aged 65 years and above
Influenza has been an acknowledged cause of respiratory disease for decades. However, considerable related, and often unappreciated, disease burden stems from cardiovascular complications, exacerbations of underlying medical conditions and secondary respiratory complications, with the highest burden in the elderly. This study combines the gold standard method of a randomized controlled trial with real-world data collection […]
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In category NewsVaccine-preventable disease incidence of pneumococcal conjugate vaccine in the Finnish invasive pneumococcal disease vaccine trial
Streptococcus pneumoniae, pneumococcus, causes a number of different clinical syndromes including invasive diseases like meningitis and sepsis/bacteraemia, pneumonia and upper respiratory infections like otitis media in children and sinusitis in adults. The disease burden is highest among infants and the elderly. Pneumococcus remains the number one killer in developing countries, especially due to the high disease burden of pneumonia, but mortality […]